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PLGA
PLGA(polylactic-co-glycolic acid)´Â Lactic acid - Glycolic acidÀÇ °øÁßÇÕü·Î¼
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CAS No : 26780-50-7
PLGA-50 ½Ã¸®Áî : Lactic acid - Glycolic acid 50 : 50 °øÁßÇÕü
»óÇ°¹øÈ£ | Æò±ÕºÐÀÚ·®(M.W) | Á¡µµ(dl/g) | Æ÷Àå´ÜÀ§ | °¡°Ý(ºÎ°¡¼¼ º°µµ) |
PLGA-5005-01 |
5,000 |
0.088-0.102 |
1g |
150,000¿ø |
PLGA-5005-05 |
5,000 |
0.088-0.102 |
5g |
500,000¿ø |
PLGA-5005-25 |
5,000 |
0.088-0.102 |
25g |
1,300,000¿ø |
PLGA-5010-01 |
10,000 |
0.122-0.143 |
1g |
150,000¿ø |
PLGA-5010-05 |
10,000 |
0.122-0.143 |
5g |
500,000¿ø |
PLGA-5010-25 |
10,000 |
0.122-0.143 |
25g |
1,300,000¿ø |
PLGA-5015-01 |
15,000 |
0.154-0.186 |
1g |
150,000¿ø |
PLGA-5015-05 |
15,000 |
0.154-0.186 |
5g |
500,000¿ø |
PLGA-5015-25 |
15,000 |
0.154-0.186 |
25g |
1,300,000¿ø |
PLGA-5020-01 |
20,000 |
0.187-0.229 |
1g |
150,000¿ø |
PLGA-5020-05 |
20,000 |
0.187-0.229 |
5g |
500,000¿ø |
PLGA-5020-25 |
20,000 |
0.187-0.229 |
25g |
1,300,000¿ø |
PLGA-75 ½Ã¸®Áî : Lactic acid - Glycolic acid 75 : 25 °øÁßÇÕü
»óÇ°¹øÈ£ | Æò±ÕºÐÀÚ·®(M.W) | Á¡µµ(dl/g) | Æ÷Àå´ÜÀ§ | °¡°Ý(ºÎ°¡¼¼ º°µµ) |
PLGA-7505-01 |
5,000 |
0.082-0.098 |
1g |
150,000¿ø |
PLGA-7505-05 |
5,000 |
0.082-0.098 |
5g |
500,000¿ø |
PLGA-7505-25 |
5,000 |
0.082-0.098 |
25g |
1,300,000¿ø |
PLGA-7510-01 |
10,000 |
0.119-0.140 |
1g |
150,000¿ø |
PLGA-7510-05 |
10,000 |
0.119-0.140 |
5g |
500,000¿ø |
PLGA-7510-25 |
10,000 |
0.119-0.140 |
25g |
1,300,000¿ø |
PLGA-7515-01 |
15,000 |
0.152-0.185 |
1g |
150,000¿ø |
PLGA-7515-05 |
15,000 |
0.152-0.185 |
5g |
500,000¿ø |
PLGA-7515-25 |
15,000 |
0.152-0.185 |
25g |
1,300,000¿ø |
PLGA-7520-01 |
20,000 |
0.186-0.230 |
1g |
150,000¿ø |
PLGA-7520-05 |
20,000 |
0.186-0.230 |
5g |
500,000¿ø |
PLGA-7520-25 |
20,000 |
0.186-0.230 |
25g |
1,300,000¿ø |
ºÐÇؼº µ¥ÀÌÅÍ
PLGAÀÇ »ýü¿¡¼ÀÇ ºÐÇؼºÀº ±× ¸ð³ë¸Ó Á¶¼ººñ¿¡ ÀÇÇÏ¿© º¯ÈÇÕ´Ï´Ù.
Á¶¼ººñ°¡ 1:1ÀÇ ¶§°¡ °¡Àå ºü¸£¸ç 1:1ÀÇ ºñ¿¡¼ ¹þ¾î³¯¼ö·Ï ´Ê¾îÁý´Ï´Ù.(±×¸² 1)
±×¸² 2¿¡ ³ªÅ¸³ª´Â °Íó·³ ¸¶ÀÌÅ©·Î ĸ½¶ÈµÈ TRH(Thyrotropin-releasing hormone)ÀÇ ¹æÃ⼺Àº
À¯»ê/±Û¸®ÄÝ»êÀÇ ºñ°¡ 50/50 > 75/25 > 100/0ÀÇ ¼ø¼·Î »¡¶óÁý´Ï´Ù.
ÀÌ°ÍÀº »ó±âÀÇ PLGAÀÇ ºÐÇؼº°ú °ü·ÃµË´Ï´Ù£®
±×¸² 3¿¡¼ º¼ ¼ö ÀÖ´Â ¹Ù¿Í °°ÀÌ ºÐÀÚ·®ÀÌ ³ôÀº ¼ø¼·Î ¸¶ÀÌÅ©·Î ĸ½¶·ÎºÎÅÍÀÇ ¾à¹° ¹æÃâ ¼Óµµ°¡ ´Ê¾îÁý´Ï´Ù£®
PLGA¸¦ ±âÁ¦·Î ÇÏ´Â Á¦Á¦¸¦ ¼³°èÇÏ´Â °æ¿ì ÃÖÀûÀÎ PLGAÀÇ Á¶¼ººñ¿Í ºÐÀÚ·®À» ¼±Á¤ÇÏ´Â °ÍÀÌ Áß¿äÇÕ´Ï´Ù£®
PLGA¸¦ ÀÌ¿ëÇÑ ¼¹æ¼º Á¦Á¦´Â ¾à¹°ÀÇ ¹æÃ⼺À» º¯È½ÃÅ°±â ¶§¹®¿¡ in vitro£¬in vivo¿¡¼
´Ù¾çÇÑ PLGA¸¦ ½ºÅ©¸®´× ÇÒ ÇÊ¿ä°¡ ÀÖ½À´Ï´Ù£®
Fig. 1. Half life of various of lactic acid and glycolic acid as copolymers implanted in rat tissue.
Fig. 2. Release profiles of TRH from PLGA microspheres with different copolymer ratios of PLGA.
Fig. 3. Effect of molecular weight of PLGA75/25 on release profiles of TRH microspheres.
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