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PLGA

PLGA(polylactic-co-glycolic acid)´Â Lactic acid - Glycolic acidÀÇ °øÁßÇÕü·Î¼­
¾à¹° Àü´Þ(Drug delivery system) ¿¬±¸¸¦ À§ÇÑ ¼¼Æ÷ ¹× Á¶Á÷ģȭ¼ºÀ» °®Ãá »ýºÐÇؼº
°íºÐÀÚÀÔ´Ï´Ù.

¹°¼ºÁ¤º¸
CAS No : 26780-50-7

 

PLGA-50 ½Ã¸®Áî : Lactic acid - Glycolic acid  50 : 50 °øÁßÇÕü

»óÇ°¹øÈ£ Æò±ÕºÐÀÚ·®(M.W) Á¡µµ(dl/g) Æ÷Àå´ÜÀ§ °¡°Ý(ºÎ°¡¼¼ º°µµ)

PLGA-5005-01

5,000

0.088-0.102

1g

150,000¿ø

PLGA-5005-05

5,000

0.088-0.102

5g

500,000¿ø

PLGA-5005-25

5,000

0.088-0.102

25g

1,300,000¿ø

PLGA-5010-01

10,000

0.122-0.143

1g

150,000¿ø

PLGA-5010-05

10,000

0.122-0.143

5g

500,000¿ø

PLGA-5010-25

10,000

0.122-0.143

25g

1,300,000¿ø

PLGA-5015-01

15,000

0.154-0.186

1g

150,000¿ø

PLGA-5015-05

15,000

0.154-0.186

5g

500,000¿ø

PLGA-5015-25

15,000

0.154-0.186

25g

1,300,000¿ø

PLGA-5020-01

20,000

0.187-0.229

1g

150,000¿ø

PLGA-5020-05

20,000

0.187-0.229

5g

500,000¿ø

PLGA-5020-25

20,000

0.187-0.229

25g

1,300,000¿ø

PLGA-75 ½Ã¸®Áî : Lactic acid - Glycolic acid  75 : 25 °øÁßÇÕü

»óÇ°¹øÈ£ Æò±ÕºÐÀÚ·®(M.W) Á¡µµ(dl/g) Æ÷Àå´ÜÀ§ °¡°Ý(ºÎ°¡¼¼ º°µµ)

PLGA-7505-01

5,000

0.082-0.098

1g

150,000¿ø

PLGA-7505-05

5,000

0.082-0.098

5g

500,000¿ø

PLGA-7505-25

5,000

0.082-0.098

25g

1,300,000¿ø

PLGA-7510-01

10,000

0.119-0.140

1g

150,000¿ø

PLGA-7510-05

10,000

0.119-0.140

5g

500,000¿ø

PLGA-7510-25

10,000

0.119-0.140

25g

1,300,000¿ø

PLGA-7515-01

15,000

0.152-0.185

1g

150,000¿ø

PLGA-7515-05

15,000

0.152-0.185

5g

500,000¿ø

PLGA-7515-25

15,000

0.152-0.185

25g

1,300,000¿ø

PLGA-7520-01

20,000

0.186-0.230

1g

150,000¿ø

PLGA-7520-05

20,000

0.186-0.230

5g

500,000¿ø

PLGA-7520-25

20,000

0.186-0.230

25g

1,300,000¿ø

 

ºÐÇؼº µ¥ÀÌÅÍ

PLGAÀÇ »ýü¿¡¼­ÀÇ ºÐÇؼºÀº ±× ¸ð³ë¸Ó Á¶¼ººñ¿¡ ÀÇÇÏ¿© º¯È­ÇÕ´Ï´Ù.
Á¶¼ººñ°¡ 1:1ÀÇ ¶§°¡ °¡Àå ºü¸£¸ç 1:1ÀÇ ºñ¿¡¼­ ¹þ¾î³¯¼ö·Ï ´Ê¾îÁý´Ï´Ù.(±×¸² 1)

±×¸² 2¿¡ ³ªÅ¸³ª´Â °Íó·³ ¸¶ÀÌÅ©·Î ĸ½¶È­µÈ TRH(Thyrotropin-releasing hormone)ÀÇ ¹æÃ⼺Àº
À¯»ê/±Û¸®ÄÝ»êÀÇ ºñ°¡ 50/50 > 75/25 > 100/0ÀÇ ¼ø¼­·Î »¡¶óÁý´Ï´Ù.
ÀÌ°ÍÀº »ó±âÀÇ PLGAÀÇ ºÐÇؼº°ú °ü·ÃµË´Ï´Ù£®

±×¸² 3¿¡¼­ º¼ ¼ö ÀÖ´Â ¹Ù¿Í °°ÀÌ ºÐÀÚ·®ÀÌ ³ôÀº ¼ø¼­·Î ¸¶ÀÌÅ©·Î ĸ½¶·ÎºÎÅÍÀÇ ¾à¹° ¹æÃâ ¼Óµµ°¡ ´Ê¾îÁý´Ï´Ù£®

PLGA¸¦ ±âÁ¦·Î Çϴ Á¦Á¦¸¦ ¼³°èÇÏ´Â °æ¿ì ÃÖÀûÀÎ PLGAÀÇ Á¶¼ººñ¿Í ºÐÀÚ·®À» ¼±Á¤ÇÏ´Â °ÍÀÌ Áß¿äÇÕ´Ï´Ù£®
PLGA¸¦ ÀÌ¿ëÇÑ ¼­¹æ¼º Á¦Á¦´Â ¾à¹°ÀÇ ¹æÃ⼺À» º¯È­½ÃÅ°±â ¶§¹®¿¡ in vitro£¬in vivo¿¡¼­
´Ù¾çÇÑ PLGA¸¦ ½ºÅ©¸®´× ÇÒ ÇÊ¿ä°¡ ÀÖ½À´Ï´Ù£®   

Half life by PLGA composition

Fig. 1. Half life of various of lactic acid and glycolic acid as copolymers implanted in rat tissue.

Release profiles of TRH from PLGA microspheres with different copolymer ratios of PLGA.

Fig. 2. Release profiles of TRH from PLGA microspheres with different copolymer ratios of PLGA.

Effect of molecular weight of PLGA75/25 on release profiles of TRH microspheres.

Fig. 3. Effect of molecular weight of PLGA75/25 on release profiles of TRH microspheres.

º» Á¦Ç°Àº ¿¬±¸ ¹× ½ÇÇè ÀÌ¿ÜÀÇ ¸ñÀûÀ¸·Î »ç¿ëÇÏ½Ç ¼ö ¾ø½À´Ï´Ù.